NDGA对人恶性胶质瘤细胞系SHG-44细胞增殖抑制机理的研究

• 作者: 卞修武 辛榕 郭德玉 陈意生
• 来源期刊: 中国学术期刊文摘
• 学科: 医学
• 关键词: NDGA glioma proliferation inhibition
• 年，卷（期）: 1998,（9）
• 页码范围: 1128-1129
• 页数: 2页
• 分类号: R74
• 语种: 中文

摘要

To investigate the mechanisms of nordihydroguaiaretic acid (NDGA) on cell proliferation inhibition of human glioma cell line SHG-44, the techniques of cell culture, immunohisto-chemisty, in situ hybridization and FCM are employed in this experiment. The results are obtained that ① SHG-44 cell proliferation was blocked in G1→S phase by NDGA, ② The expression of P16 gene in cells increased and cyclin D1, CDK4 gene decreased after treatment of NDGA. These data suggest that effect of NDGA on cell proliferation inhibition of SHG-44 is probably completed by regulating the activity of CDK4.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	卞修武	第三军医大学病理学教研室	141	858	14.0	19.0
2	陈意生	第三军医大学病理学教研室	55	365	11.0	15.0
3	郭德玉	第三军医大学病理学教研室	53	368	11.0	16.0
4	辛榕	第三军医大学病理学教研室	28	231	10.0	13.0