THE IMMUNOLOGICAL STUDIES ON PROLIFERATIVE INTRAOCULAR DISORDERS: INVESTIGATION OF ACTIVATED LYMPHOCYTES, MACROPHAGES AND HLA-DR

• 来源期刊: 眼科学报
• 学科: 医学
• 年，卷（期）: 1998,（1）
• 页码范围: 35-40
• 页数: 6页
• 分类号: R770.2
• 语种: 中文

摘要

<正> Purpose: To investigate whether activated B lymphocytes ( CD23 ) , activated T lymphocytes (CD25) ,macrophages(CD68) and human leucocyte antigen class II antigen (HLA- DR) were existed in epiretinal membranes (ERMs) and subretinal membranes (SRMs) of prolif-erative intraocular disorders (PID).Methods : Twenty specimens of ERMs from rhegmatogenous retinal detachment with prolifera-tive vitreoretinopathy( PVR), traumatic PVR and secondary traction retinal detachment, and two specimens of SRMs from rhegmatogenous retinal detachment with PVR and traumatic PRV were studied using immunohistochemical staining.Results: CD68 and HLA - DR were found in all specimens, CD23 and CD25 in 4 cases of ERMs and in 1 case of SRMs, respectively.Conclusions : 1. The ERMs and SRMs of different etiology shared a common basis of inflammation and immunopathology. 2. There would be secondary cellular and humoral immunity in the ERMs and the SRMs of PID. Eye Science 1998; 14:35 - 40.