Investigation of retention and chiral recognition mechanism using quantitative structure-enantioselectivity retention relationship in high performance liquid chromatography

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2000,（2）
• 所属期刊栏目: Articles
• 页码范围: 194-200
• 页数: 7页
• 分类号: O6
• 语种: 英文

摘要

The enantiomers of a series of fourteen O-ethyl O-(substituted) phenyl N-isopropyl-phosphoroamidothioates have been separated by high performance liquid chromatography (HPLC) on the Pirkde-type chiral stationary phase. Seven molecular descriptors were lculated and four .significant descriptors were chosen to correlate against the experimental Ink′ values in order to form thequantitative structure-enantioselectivity retention relationships (QSERRs). Through the QSERRs, the retention and enantioselectivity meehanism were examined.