A new synthesis of cytotoxic (＋)-7-epi-Goniofufurone

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2000,（2）
• 所属期刊栏目: Articles
• 页码范围: 225-231
• 页数: 7页
• 分类号: O6
• 语种: 英文

摘要

Cytotoxic styryl lactone, ( ＋ )-7-epi-Goniofufurone (1), has been prepared with a new route from 3-O-beazyl-1,2-O-isopropylidene-5- C- phenyl- β- L-ido- pentofuranose (6), a derivative of ( ＋ )-glucose. Treatment of 14 with HCl solution cleaved TBDMS and isopropylidene and simultaneously caused ring closure to afford 1 while treatment of 14 with Sc(OTf)3only removed TBDMS to give 15.