Lipophilicity determination of N-( benzothiazol-2-yl )-α-amino alkyl phosphonic diesters by RP-HPLC and RP-HPTLC

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2000,（6）
• 所属期刊栏目: Articles
• 页码范围: 872-876
• 页数: 5页
• 语种: 英文

摘要

Using methanol-water mixtures as the mobile phase, the chromatographic retebtion parameters k' and R1 were determ1ined by reversed-phase high-perfor mance liquid chromatography (RP-HPLC) and reversed-phase high-performance thin-layer chromatograhy (RP-HPILC) for N-(benzothiazol-2-yl)-α-amino alkyl phosphonic diesters and the correlation with lipophilicity parameter (ClogP) was established. Logk wues obtained from RP-HPLC and Rmo values obtained from RP-HPTLC can be used to evaluate the lipophilicity of this kind of compounds. Chromatographic method is a good alternaive for lipophilicity measurement.