Analysis of Peripheral T-Lymphocyte Subpopulations in Patients with Early Syphilis by Flow Cytometry

• 来源期刊: 中华性传播感染杂志（英文版）
• 学科: 医学
• 关键词: Syphilis . T-lymphocyte subpopulation Flowcytometry
• 年，卷（期）: 2001,（2）
• 页码范围: 24-26
• 页数: 3页
• 分类号: R752
• 语种: 英文

摘要

Objective: To study the cellular immunity function of patients with early syphilis and the effects on immune modifiers Esberitox N or IFN.Methods: T-lymphocyte subpopulations of the peripheral blood in 44 patients with syphilis and 40 healthy controls were examined by flow cytometry.Results: The number of CD4+ cells and the CD4+/CD8+ ratio in patients with syphilis were found to be significantly lower than those in the control (P＜0.01), while the number of CD8+ cells was higher than that in the control (P＜0.01). The CD4+/CDs+ ratio in those with active disease was lower than that in those who had been cured (P＜0.05). The CD4+ count and the CD4+/CDs+ ratio in those treated with antibiotics alone (Penicillin G or Cephalosporins) were lower than those treated with both antibiotics and immunomodulators (P＜0.05).Conclusions: Cellular immunity in the patients with early syphilis was prominently suppressed, and treatment with immunomodulators may be helpful for the recovery of cellular immunity of these patients.