Objective To evaluate the therapeutic effects of radionuclide-labled microsphere by intratumoral injection into 18 patients with superficial matastasis tumor for treatment. Methods 18 patients with superficial matastasis were treated with radionuclide-labled microsphere (90 Y-GTMS and 32 P-GTMS) by multi-point intratumoral injection. Each injection dose was 11.1 ~ 18.5MBq/g (tumor). Results 1 patient vas relieved completely, 9 were relieved partly, 5 were improved and 3 kept stable. The total rate of relief and virtual value were 55.6% and 83.3% respectively. Conclusion Topical treatment by using radionuclide may help diminish the tumor, control its progress and ease the symptoms. Thus it can be used as a supplement of routin treatment of tumors and it should do some work in therapy of malignant tumors in late stages.