THE EFFECT OF ERIGERON BREVISCAPUS ON PROLIFERATION OF PULMONARY ARTERY SMOOTH MUSCLE CELLS IN HYPOXIC PORCINES

• 来源期刊: 同济医科大学学报(外文版)
• 学科: 医学
• 关键词: 冠心病 临床与实验 治疗 中国急救医学 脑梗塞 灯盏花素注射液 抑制剂 实用医学杂志 疗效分析
• 年，卷（期）: 2001,（3）
• 页码范围: 206-208
• 页数: 3页
• 分类号: R285.5
• 语种: 中文

摘要

In order to study the effect of Erigeron Breviscapus (EB) on proliferation of pulmonary artery smooth muscle cells (PASMC) in hypoxic porcines, immunohistochemical and MTT methods were employed to measure the proliferation of PASMC. It was found that the proliferation of PASMC in porcines was obvious, and the expression of proliferating cell nuclear antigen (PCNA) was significantly high within 48 h after exposure to hypoxia. The EB could inhibit the proliferation and the expression of PCNA in PASMC under hypoxia, but it had no effect on the proliferation and expression of PCNA in PASMC under normal condition. The EB could inhibit the proliferation and the expression of PCNA in PASMC induced by phorbol 12-myristate 13-acetate (PMA), an agonist of PKC in normal and hypoxic conditions. It was concluded that the hypoxia could enhance the proliferation and expression of PCNA in PASMC. The EB can inhibit the proliferation and expression of PCNA in PASMC under hypoxia through PKC-signal way. The EB may be used in treating the pulmonary hypertension by inhibiting the proliferation of PASMC and the pulmonary vascular remodeling.