EFFECT OF XIAOKUILING PRESCRIPTION ON THE EXPRESSION OF HSP_(72) , HSP B IN GASTRIC MUCOSA OF PATIENTS WITH HELICOBACTER PYLORI ASSOCIATED DUODENAL ULCER

• 来源期刊: 同济医科大学学报(外文版)
• 学科: 医学
• 关键词: 快速测定 幽门螺杆菌 中国中西医结合杂志 热休克蛋白表达 微量蛋白 劳里法 健脾益气 中国人民解放军 中药药理学 乙酸慢性胃溃疡
• 年，卷（期）: 2001,（4）
• 页码范围: 310-313
• 页数: 4页
• 分类号: R573.02
• 语种: 中文

摘要

In order to investigate the mechanism of Xiaokuiling prescription (XKL) in the treatment of Helicobacter pylori (HP) associated duodenal ulcer (DU) and the pathophysiologic role of heat shock proteins (HSPs) in the healing of ulcer, the expression of HSP 72 and HSP B in gastric mucosa was detected by using SABC immunohistochemistry method and processed by micro image analysis system. The method of Western blotting was used to measure the contents of HSP 72 and HSP B in the tissue emulsion of gastric mucosa. The results were as follows: (1) HSP 72 expression of the gastric mucosa in the treated group was obviously increased as compared with that in the control group ( P <0.05); (2) HSP B expression of the gastric mucosa in the treated group was significantly decreased as compared with that in the control group ( P <0.01). It was suggested that the increased expression of HSP 72 and the elimination of HP might be related to the mechanism of action of XKL. HSPs might play an pathological and physiological role in the process of healing of gastric ulcer.