比较饮食摄取l-卡尼汀和dl-卡尼汀对氨中毒和肝代谢的作用

• 作者: Gisele LOPES Roberto B BAZOTTE Rui CURI Vilma A F G GAZOLA
• 来源期刊: 中国药理学报(英文版)
• 学科: 医学
• 关键词: 卡尼汀 肝 代谢 糖原异生 氨
• 年，卷（期）: 2001,（4）
• 所属期刊栏目: 研究原著
• 页码范围: 305-310
• 页数: 6页
• 分类号: R96
• 语种: 英文

摘要

AIM: To compare the effects of chronic supplementation with l-camitine (LCT) and dl-carnitine (DLC) on am monia toxicity and hepatic metabolism. METHODS: Three groups of male adult rats were studied: 1) supple mented with LCT ( 1.2 mmol· kg- 1 · d- 1 ), 2 ) supple mented with DLC ( 1.2 mmol· kg- 1· d- 1 ), and 3) con trol group (COG) not supplemented. RESULTS: The treatment with LCT decreased the toxicity to ammonia. However, the supplementation with DLC did not show any significant effect. In contrast, the effects of the supplementation with LCT and DLC on hepatic metabolism were quite similar, ie, both groups showed: (a) intensified ammonia uptake and decreased urea pro duction from ammonia; (b) increased glucose and urea production from L-glutamine (5 mmol/L). CONCLU SION: The results suggested that LCT supplementation might protect against ammonia toxicity by extra-hepatic mechanisms.