半胱胺对小鼠疼痛感受的影响

• 来源期刊: 中国药理学报(英文版)
• 学科: 医学
• 关键词: 半胱胺 疼痛测定 镇痛药
• 年，卷（期）: 2001,（7）
• 所属期刊栏目: 研究原著
• 页码范围: 603-608
• 页数: 6页
• 分类号: R96
• 语种: 英文

摘要

AIM: The present study was carried to study the effects of cysteamine on nociception in mice. METHODS: The pain assays were the hot plate and the tail flick test. RESULTS: When cysteamine, a drug well known as a somatostatin depletor, was administered 1 and 4 but not 24 h before the tests (hot plate, tail flick), the nocicep tive threshold was elevated when the drug was adminis tered at high doses (50 and 100 mg/kg) while at a lower dose (10 mg/kg), it was able to elevate the nociceptive threshold in the hot plate test only. In the hot plate as well the tail flick test cysteamine effects are reversed by nalox one administration and potentiated by morphine adminis tration, whereas neither somatostatin nor cyclo-(7-amino heptanoyl-Phe-D-Trp-Lys-Thr [ Bzl ], a reported somato statin antagonist, changes cysteamine effects. CON CLUSION: These results suggest that cysteamine effects on the nociceptive threshold in the hot plate and tail flick test may be mediated by cysteamine interference with the opioid system.