Low-valent Titanium Induced Reductive Coupling of o-Nitro-phenylazide with Benzoyl Substituted Ketene Dithioacetals: a Novel Synthesis of 4-Aryl-2-methylthio-3H-1,5-benzodiazepines

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2001,（10）
• 页码范围: 996-998
• 页数: 3页
• 分类号: O6
• 语种: 英文

摘要

Treated with the low-valent titanium derived from TiCl4/Sm system, o-nitrophenylazide could produce the intermediate 2in situ, which reacted with benzoyl substituted ketene dithioacetals to afford 4-aryl-2-methylthio-3H-1,5-benzodiazepines in good yields under mild and neutral conditions.