A Practical Approach to the Synthesis of Insect Antifeedant Tonghaosu Analogs

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2001,（12）
• 页码范围: 1254-1258
• 页数: 5页
• 分类号: O6
• 语种: 英文

摘要

Tonghmosu and its analogs are a class of structurally interest-ing spiroketal emol-ether compounds.A practical route to fu-randiol,a key intermediate for their syntheses,was developed.Using Friedel-Crafts benzoylation of 3-(2-furyl)propylacetate,a diarylketone was obtained in high yield,which wasfurther transformed into corresponding furandiol by reductionwith NaBH4 in basic medimn with simultaneous ester hydroly-sis.The furandiol was then cyclized into the desired spiroketalenol-ether compound in the presence of CuSOn@5H2O.``