Objectives: To make a summary of the trends of HIV/AIDSepidemic and route of transmission in Shenzhen from 1992 to2000 to provide scientific evidence for the policy-maker toformulate strategies of HIV/AIDS prevention and control inShenzhen.Method: To analyze HIV/AIDS surveillance data inShenzhen from 1992 to 2000 by software Epi-Info.Results: One hundred and two HIV positive cases including18 AIDS cases (three cases deceased) were identified inShenzhen from 1992 to 2000. Among the 102 cases, thoseinfected via sex were 46.0%, intravenous drug use 42.9%.Blood donation 7.8%, blood transfusion recipient 3.9%, andindeterminate 2 %.Conclusion: In Shenzhen, HIV/AIDS infection is spreadingand increasing rapidly. Effective prevention measures must betaken to reduce the HIV prevalence as soon as possible.