One-Pot Syntheses of 3, 4-Dihydropyrimidine-2 ( 1H )-thiones Catalyzed by La(OTf)3

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2002,（5）
• 页码范围: 427-430
• 页数: 4页
• 语种: 英文

摘要

A general and practical procedure for the syntheses of 3,4-dihydropyrimidine-2(1H)-thiones by a one-pot condensation of aldehyde, β-ketoester or β-diketone and thiourea using La(OTf)3 as the catalyst is described. Mild reaction conditions,excellent yields as well as the environmentally friendly character ofLa( OTf)3 make it an important alternative to the classic acid-catalyzed Bigineili' s reaction.