Human Papillomavirus Genotypes and Expression of p53 and p21WAF1 in Condyloma Acuminatum

• 来源期刊: 中华性传播感染杂志（英文版）
• 学科: 医学
• 关键词: Human papillomavirus p53 p21 WAF1
• 年，卷（期）: 2002,（3）
• 页码范围: 17-19
• 页数: 3页
• 分类号: R511
• 语种: 英文

摘要

This study investigated the relationship betweenhuman papillomavirus (HPV) genotype and expression of p53and p21WAF1. Expression of p53 and p21WAF1 in 35 cases ofcondyloma acuminatum specimens infected by HPV6/11andHPV16/18 were studied using immunohistochemical staining.All specimens of the condyloma acuminatum case were positivefor expression of p53 and p21 WAFt. The expression of p53 incondyloma acuminatum infected by HPV16/18 wassignificantly lower than that in specimens infected byHPV6/11.However, expression of p21WAF1 between the twogroups was not significantly different. Expression of p53 incondyloma acuminatum is likely related to HPV genotype,expression of p21WAF1 was not related to HPV genotype.