DYNAMIC MODEL AND SIMULATION OF THE PLATELETS' ROLE IN BLOOD COAGULATION

• 来源期刊: 力学学报（英文版）
• 学科: 物理学
• 年，卷（期）: 2002,（4）
• 页码范围: 420-428
• 页数: 9页
• 分类号: O3
• 语种: 英文

摘要

In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments. Based on qualitative analysis and mathematical simulation, a series of conclusions about the influence of the activation rate of factor Ⅷ and factor Ⅸ on the generation of thrombin (Ⅱa) are drawn. It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade. The value is related to the binding constant d2 of the platelet.The stability of the equilibrium value is also related to the pro-coagulation stimulus.This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin. The proportion of platelets activated at any given time is designated c. To each c, we obtain a maximum concentration of thrombin. It is evident that when the level of factor IX is below 1% of the normal level, the rate of thrombin generation reduces dramatically, resulting in severe bleeding tendency.