Synthesis of Thiourea Derivatives on Soluble Polymeric Support

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2002,（2）
• 页码范围: 178-182
• 页数: 5页
• 语种: 英文

摘要

A modified poly(ethylene glycol) ( PEG ) has been developed as the soluble polymeric supports for liquid phase synthesis of novel thiourea derivatives. In each step of the sequence, the PEG-bound products were precipitated in cold Et2O and the unreacted materials and by-products were removed by simple filtration. The progress of reaction, purity of the isolation and the structure of the PEG-bound products were easily monitored by TLC, IR and 1H NMR spectra. Representative thiourea derivatives were obtained in moderate yields with excellent purity from this modified PEG-bound product by the cleavage with 50% TFA/H2O.