Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2002,（5）
• 页码范围: 492-496
• 页数: 5页
• 语种: 英文

摘要

Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O-Isopropyl 2', 3'-O-isopropylidene uridine-5'-yl N-thiophosphoryl threonine and serine methyl esters (5a and 5b) underwent the intramolecular catalyzed hydrolysis reaction.