Transplanted neuronal precursors migrate and differentiate in the developing mouse brain

• 来源期刊: 细胞研究(英文版)
• 学科: 生物学
• 关键词: subventricular zone (SVZ), neuronal precursor, cell transplantation, migration, differentiation,mouse.
• 年，卷（期）: 2002,（4）
• 页码范围: 223-228
• 页数: 6页
• 分类号: Q2
• 语种: 中文

摘要

The subventricular zone (SVZ), lining the lateral ventricle in forebrain, retains a population of neuronalprecursors with the ability of proliferation in adult mammals. To test the potential of neuronal precursorsin adult mice, we transplanted adult SVZ cells labeled with fluorescent dye PKH26 into the lateral ventricleof the mouse brain in different development stages. The preliminary results indicated that the graftedcells were able to survive and migrate into multiple regions of the recipient brain, including SVZ, the thirdventricle, thalamus, superior colliculus, inferior colliculus, cerebellum and olfactory bulb etc; and the amountof survival cells in different brain regions was correlated with the development stage of the recipient brain.Immunohistochemical studies showed that most of the grafted cells migrating into the specific target couldexpress neuronal or astrocytic marker. Our results revealed that the neuronal precursors in adult SVZstill retained immortality and ability of proliferation, which is likely to be induced by some environmentalfactors.