Objective Exploring therapy of skin ulcer. Method Using gauze with high - osmoticmetronidazole and glucose fluid fill up ulcer after conventional therapy. Observing proliferation of bacteriabefore and 1 week after therapy and comparing the healing time beween experimental and control group.Result Experintal group can inhibit proliferation of becteria and reduce healing time. ConclusionsHigh- osmotic metronidazole and glucose fluid is a safe and effective therapy to skin ulcer.