A Formal Synthesis of ( + )-Cassiol Exploiting Meyers' Bicyclic Lactam Methodology

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2002,（11）
• 页码范围: 1439-1444
• 页数: 6页
• 语种: 英文

摘要

A formal synthesis of ( + )-cassiol using (1S,2S)-2-amino-1-(4- nitrophenyl)-1,3-propanediol as chiral auxiliary is reported.The quaternary chiral center in the molecule was constructed by sequential alkylation of a bicyclic lactam (prepared from the aforementioned auxiliary and 5-oxo-heptanlic acid) with methyl iodide and benzyloxymethyl chloride.