EFFECT OF BISPHENOL A AND CO-ADMINISTRATION OF BISPHENOL AAND VITAMIN C ON EPIDIDYMIS OF ADULT RATS:A HISTOLOGICAL AND BIOCHEMICAL STUDY

• 来源期刊: 亚洲男性学杂志(英文版)
• 学科: 医学
• 关键词: 川东
• 年，卷（期）: 2003,（3）
• 页码范围: 203-208
• 页数: 6页
• 分类号: R96
• 语种: 中文

摘要

Aim: To study the effect of bisphenol A on the epididymis and epididymal sperm of rats and the possible amelioration action of co-administration with vitamin C. Methods: Male Wistar rats were orally administered bisphenol A (0.2 μg·kg-1·day-1, 2 μg·kg-1·day-1 and 20 μg·kg-1·day-1) and 0.2 μg, 2μg and 20 μg bisphenol A + 40 mg vitamin C·kg-1·day-1 for 60 days. On day 61, rats were killed with anesthetic ether and sperm collected from epididymis were used for assessment of sperm count, motility and viability and biochemical studies. A 1 % homogenate of epididymis was prepared and used for biochemical estimations. Caput, corpus and cauda epididymis were fixed in Bouin's fixative for histological studies. Results: Administration of bisphenol A caused a reduction in the epididymal sperm motility and count and the sperm viability remained unchanged. The activities of superoxide dismutase and glu-tathione peroxidase decreased, while the levels of lipid peroxidation increased in epididymal sperm an