人胎盘提取液的抗炎和抗血小板聚集作用

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 胎盘提取物 炎症 角叉菜胶 血小板聚集 腺苷二磷酸
• 年，卷（期）: 2003,（2）
• 所属期刊栏目: 研究原著
• 页码范围: 187-192
• 页数: 6页
• 分类号: R9
• 语种: 英文

摘要

AIM: To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract (HPE, Placentrex).METHODS: The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin (5-HT),and prostaglandin E1 (PGE1) induced edema in acute model and cotton pellet induced granuloma on sub-acutemodel. Anti-platelet aggregation was studied against protection of adinosine diphosphate (ADP)-induced aggrega-tion of human platelet through in vitro study. RESULTS: HPE showed positive results both in acute and sub-acutemodels of inflammation. Highly significant (P＜0.01) results were obtained against 5-HT induced acute inflamma-tion and cotton pellet induced sub-acute inflammation in comparison with standard (diclofenac sodium) and control(normal saline) drugs. The anti-inflammatory property of HPE in animal model was well supported with clinicalstudy of platelet aggregation. There was highly significant (P＜0.01) inhibition of platelet aggregation with HPE atdifferent doses against ADP. CONCLUSION: Our data suggest that human placental extract may be useful insuppressing inflammation and platelet aggregation.