依前列醇多样的信号选择

• 作者: Helen WISE
• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 依前列醇 IP受体 过氧化物酶体增殖因子活化受 体 受体转换
• 年，卷（期）: 2003,（7）
• 所属期刊栏目: 综述
• 页码范围: 625-630
• 页数: 6页
• 分类号: R96
• 语种: 英文

摘要

The fate of a cell following stimulation by the prostanoid prostacyclin is cell specific, depending not only onthe ability of prostacyclin to activate the cell surface prostacyclin (IP) receptor and regulate its coupling to variousG proteins, but also on its ability to act intracellularly via the nuclear peroxisome proliferator-activated receptorfamily (PPAR). This review will highlight the different signalling options available to prostacyclin, and discuss theconsequences for cell responses.