果糖及血管内皮生长因子引起仓鼠颊囊血浆外渗

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 糖尿病 毛细血管通透性 内皮生长因子 果糖
• 年，卷（期）: 2003,（3）
• 所属期刊栏目: 研究原著
• 页码范围: 207-211
• 页数: 5页
• 分类号: R9,R318
• 语种: 英文

摘要

AIM: To determine in the hamster cheek pouch whether or not the changes in plasma extravasation induced byvascular endothelial growth factor (VEGF) could be affected by fructose diet. METHODS: Hamsters were sub-jected to control drinking water or to water containing fructose (10 %) for 18 weeks. RESULTS: The fructose dietinduced a small but significant increase in glycemia (0.80±0.11 and 1.09±0.15, n= 8 and 9 for control and fructose-treated animals, respectively, P＜0.05). Bradykinin-induced plasma extravasation was not affected by the fructosediet while the effects of VEGF were markedly increased (maximal number of leakage sites: 76±20 and 126±55, n =8 and 9 for control and fructose-treated animals, respectively, P＜0.01). CONCLUSION: Even moderate changesin glycemic levels can produce profound alteration in the VEGF response.