The structure and magnetic properties of Nd0.5Pb0.5-xSrxMnO3 (0 ≤ x ≤0.4) manganites were systematicallyinvestigated. Significant changes in Curie temperature and metal-insulator (MI) transition temperature of the sampleswere observed. All samples exhibited a transition from paramagnetic semiconducting to ferromagnetic metallic state.Curie temperature TC and the MI transition temperature Tp increased with increasing Sr content. We attributed thesebehaviours to the enhancing of both the double exchange mechanism and the Jahn-Teller electron-phonon coupling.