Lyon遗传性高血压大鼠:一种低肾素性高血压动物模型

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 高血压 肾素 血管紧张素Ⅱ 肾素-血管紧张素系统 遗传学 大鼠
• 年，卷（期）: 2003,（1）
• 所属期刊栏目: 综述
• 页码范围: 1-6
• 页数: 6页
• 分类号: R318
• 语种: 英文

摘要

This paper reviews the data which demonstrate that Lyon genetically hypertensive (LH) rats exhibit a low renin form of hypertension. Since when compared to normotensive controls, LH rats exhibit a low renin release and are salt-sensitive. Despite this, the blockade of the renin-angiotensin system normalizes the blood pressure level and the regional blood flows in LH rats. Such a discrepancy between the compulsory presence of angiotensin Ⅱ for the hypertension to develop and the low level of renin release seen in LH rats led to two hypotheses: 1) the existence of an early, short lasting increase of renin release which would be sufficient for the occurrence of a stable hypertension;2) an hypersensitivity to the effects of angiotensin Ⅱ. The study of the long-term effects of early short lasting blockades of the renin-angiotensin system allowed to exclude the first hypothesis. Concerning a hypersensitivity to the effects of angiotensin Ⅱ, it was found to exist in the preglomerular vessels of LH rats. This increased response of renal vessels to angiotensin Ⅱ may well explain the low renin form of hypertension of our model and therefore represents an important field for further research.