Electron scattering from molecules in the intermediate- and high-energy range is investigated employing the devel-oped semi-empirical formula for electron scattering from diatomic molecules. Total cross sections of e-CH4 scatteringare obtained over an incident energy range of 10-5000eV. The results agree well with other available experimental andtheoretical data. According to our formula, some quantitative information of single Yukawa potential are also obtained.