Analysed and summarized the dynamics and chemical factors in the co (coagulation)-flocculation process. A completely new definition for co-flocculation was given. If a colloid particle didn't contact with drug to emerge (physical) chemical effect, the possibility for the colloid particle to coagulate (flocculate) was rather small, only at the flocculation stage; it may be caught by net or settled by differential sedimentation. Base on several assumed important premises, the several steps and physical model of co-flocculation process were given, and the mixing, coagulation and flocculation were proposed according to their essentiality.