STUDIES ON MICRODELETION OF GENES RELEVANT TO SPERMATOGE NESIS IN INFERTILE MEN

• 来源期刊: 亚洲男性学杂志(英文版)
• 学科: 生物学
• 年，卷（期）: 2004,（1）
• 页码范围: 66
• 页数: 1页
• 分类号: Q987
• 语种: 中文

摘要

Objective: To study the relationship between relevant gene micro-deletion and spermatogenesis in infertile men. Methods: To analyze the relevant genes of the Y-chromosome and the karyotype of peripheral blood chromosome in 149 azoospermic/sever oligo-spermic infertile men and 100 normal controls by multipolymerase chain reaction (PCR). Results: Microdeletions in different gene segments of the Y-chromosome were present in 11 cases of the infertile group (7.38 %). No microdeletion in the corresponding areas was found in the controls. The incidence of abnormal karyotype in the infertile group was 14.09 % and in the controls, 2 %. In the 11 infertiles with microdeletion in different gene segments, only one had abnormal karyotype, indicating no relativity between the two. Conclusion: Microdeletion of Y-chromosome may be an important cause of male infertility.