异丙酚用于麻醉诱导导致注射部位的疼痛或不适感可在28%-90%的病人发生,临床中曾试图采用多种方法来防止异丙酚注射痛。包括在异丙酚中加入利多卡因或血管扩张剂混合注射,都一定的疗效,而用硫喷妥预处理防止异丙酚注射痛,临床上尚无研究。为此Agarwal等(Agarwal A,Ansari MF,Qupta D.Pretreatment with thlopental for prevention of pain associated with propofol injection.Anesth Analg 2004:98:683—6)选择124例病人随机分为四组,