Synthesis and Characterization of α-HexadecyI-DOTA and its Gd(Ⅲ) Chelate

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（5）
• 页码范围: 502-504
• 页数: 3页
• 语种: 英文

摘要

Synthesis and characterization of the ligand,10-(a-hexadecylcarboxymethyl)-1,4,7,10-tetraazacyclododecane1,4,7-triacetic acid (H4L),and its Gd(Ⅲ) chelate are described.Protonation constants for H4L ( lg KHi= 10.52,9.45,4.74,4.10) and the stability constant for GdL (lg KGdL- =24.50) were determined by potentiometric titrations.The results obtained show that the ligand still maintains the strong chelating properties of the parent DOTA (1,4,7,10-tetraazacyclododecane-N,N',N"N'"-tetraacetic acid) after introduction of a linear chain hexadecyl group at the acetic side chain of DOTA,and its basicity is not significantly altered.