Synthesis of Novel 1,3-Dioxolane Nucleoside Analogues

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（12）
• 页码范围: 1425-1431
• 页数: 7页
• 语种: 英文

摘要

Novel 1,3-dioxolane C-nucleoside analogues of tiazofurin 2-(2-hydroxymethyl-1,3-dioxolan-4-yl)-1,3-thiazole-4-carboxamide as well as N-nucleoside analogues of substituted imidazoles 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4-nitroimidazole and 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4,5-dicyanoimidazole were synthesized frommethyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1H NMR, 13C NMR spectra and elemental analysis.