Studies on the Interaction between Rutin and DNA in the Absence and Presence of β-Cyclodextrin by Electrochemical and Spectroscopic Methods

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（11）
• 页码范围: 1325-1329
• 页数: 5页
• 语种: 英文

摘要

The interactions between rutin or the inclusion complex of rutin-β-cyclodextrin and DNA were investigated by means of cyclic voltammetry, UV-vis absorption spectroscopy and fluorescence emission spectroscopy. The apparent binding constant of rutin with DNA is found to be 2.9×104 L/mol. The results showed that the benzopyranic-4-one plane of rutin mainly intercalated into DNA in the absence of β-cyclodextrin, while the catecholic portion of rutin was located in the double helix of DNA in the presence of β-cyclodextrin.