Synthesis of the Active Stilbenoids by Photooxidation Reaction of trans-ε-Viniferin
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摘要:
Two new stilbenoids, cis-ε-viniferin (3) and 2b,14b-dehydro-bisresveratrol (4) were synthesized by photooxidation reaction of trans-ε-viniferin (2) prepared from trans-resveratrol (1). Pentamethoxyl trans-ε-viniferin (5) and pentamethoxyl cis-ε-viniferin (6) were also obtained by methylation of trans-ε-viniferin (2) with (MeO)2SO2. Their structures were elucidated on the basis of spectral evidence. Compounds 3 and 4 showed potent inhibition of TNF-α at concentrations of 10-5 mol·L-1 with inhibitory ratios of 51.43% and 36.64%,respectively.