Reaction of 2,3-Dihydro-1,5-benzothiazepines and Phenylacetyl Chloride in the Presence of Triethylamine: A New Aspect on the Formation Mechanism of Dihydro-1,3-oxazin-4-one Derivatives

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（9）
• 页码范围: 1012-1018
• 页数: 7页
• 语种: 英文

摘要

2a,4-Disubstituted 2,2a,3,4-tetrahydro-2-phenyl-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones, as well as 2-substituted 2,3-dihydro-3-phenylacetyl-2-styryl-benzothiazoles and 4a,6-disubstituted 3-benzyl-4a,5-dihydro-2-phenyl1H,6H-[1,3]oxazino[2,3-d][1,5]benzothiazepin-1-ones, were obtained from the reaction of 2,4-disubstituted 2,3-dihydro-1,5-benzothiazepines with phenylacetyl chloride in the presence of triethylamine. The mechanism for the formation of 4a,5-dihydro-1H,6H-[1,3]oxazino[2,3-d][1,5]benzothiazepin-1.-ones, 2,3-dihydro-1,3-oxazin-4-one derivatives, was suggested..