An in vitro Study on Transition from NO-Hemoglobin to Methemoglobin : Oxygen Effect

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2005,（5）
• 页码范围: 637-639
• 页数: 3页
• 语种: 英文

摘要

The nitrosyl-hemoglobin (HbNO) is the carrier of nitric oxide (NO) which is the important messenger molecule displaying multiple physiologic and pathophysiologic roles. However it is still not clear for the fate of HbNOmolecules during the venous-arterial transit. In this letter, the HbNO transition in vitro was studied by using the electron paramagnetic resonance (EPR) spectra. It was found that HbNO molecules were stable when oxygen did not exist in the system but not stable in aerobic conditions. The absorption spectra further revealed that the methemoglobin (metHb) was the product of HbNO in aerobic environment, showing that the HbNO changed to metHb when there were enough oxygen molecules in the system.