Synthesis of Fragment Derivatives of Delta Sleep-inducing Peptide (1-4) Catalyzed by Enzymes in Organic Solvents

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2005,（5）
• 页码范围: 640-642
• 页数: 3页
• 语种: 英文

摘要

Synthesis of two fragment derivatives of delta sleep-inducing peptide (DSIP) (1-4), Boc-Trp-Ala-Gly-GlyNH-NHPh (1) and Boc-Trp-Ala-Gly-GlyOEt (2), catalyzed by proteases via 2+2 or 1 +3 synthetic routes with different protecting groups at C-terminal in organic solvents was reported. The yield of N-Boc tetrapeptide with phenylhydrazinyl protecting carboxyl group at C-terminal (1) was higher than that of N-Boc tetrapeptide ethyl ester (2) by 2+2 route. The factors influencing the synthetic yield of the fragments of DSIP (1-4) were discussed.