Resveratrol enhances on the proliferation and osteoblastic differentiation of BMSCs through MAPK and ER／NO／cGMP pathways

• 作者: Ya-linLI Li-huaSONG Zhi-jieDAI Zhou-shengXIAO
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 分芽繁殖 造骨细胞 BMSCS MAPK ER/NO/cGMP 骨疾病
• 年，卷（期）: 2005,（2）
• 页码范围: 18-19
• 页数: 2页
• 分类号: R681

摘要

AIM The stimulatory effect of resveratrol ( Resv, a natural phytoestrogen) has been reported on osteoblasts in vitro, whereas cyclosporine A (CsA, an immunosuppressant) was associated with bone loss in vivo. This project is intend to investigate the in vitro effect of Resv and CsA on osteoblastic differentiation in bone marrow-derived mesenchymal stem cells (BMSCs), and tries to identify whether the MAPK or ER/NO/cGMP pathway is involved in the stimulatory effect of Resv on BMSCs.