Antinociception of ciproxifan in mice and its central mechanisms

• 作者: Hui-jingWANG Ming-huiYAO Nian-ciSHI Qin-yanGONG RongYU Ying-qingLU Zhi-liHUANG
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 止痛药 老鼠 中枢神经 神经系统用药
• 年，卷（期）: 2005,（2）
• 页码范围: 22
• 页数: 1页
• 分类号: R971.1

摘要

AIM To investigate the effects of ciproxifan (CPF), an H3 receptor antagnist, on modulation of pain transmission in mice and its central mechanism. METHODS The antinociceptive effect of CPF was observed in three hyperalgesic models of mice (hot plate test, writhing test and formalin test). At the same time, α-fluoromethylhistidine (α-FMH), a specific inhibitor of histidine decarboxylase(HDC), was used to determine whether histamine participate in this process. After formalin test, the levels of nitric oxide (NO) and prostaglandin E2 (PGE2) in brain, spinal and serum were assessed. Furthermore, the activation of neuronal nitric oxide synthase (nNOS) in brain and spinal cord was observed by immunohistology and Western blot in formalin test. RESULTS CPF produced antinociceptive effect inall of the three hyperalgesic models.