Neuroprotective effects of prostaglandin A1 and its effect on IKK／IkB／NF-kB／c-myc signaling pathway in rat models of permanent focal cerebral ischemia

• 作者: Hui-lingZHANG Zhen-lunGU Zheng-hongQIN
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 神经原纤维 PGA1 前列腺素A1 IKK/IkB/NF-kB/c-myc 信号路径 老鼠 大脑疾病
• 年，卷（期）: 2005,（2）
• 页码范围: 24-25
• 页数: 2页
• 分类号: R742

摘要

AIM Prostaglandin A1(PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis ofcultured SH-SY5Y cells, suggesting that PGA1 may have neuroprotective efficacy, possibly mediated by inhibition of NF-kB activation. The present study evaluated the neuroprotective potential of PGA1 and its effect on IKK/I( B/NF-kB/c-myc signaling pathway in rat models of permanent focal cerebral ischemia. METHODS Permanent middle cerebral artery occlusion (pMCAO) model was constructed by intraluminal suture cannulation through the internal carotid artery in Wistar rats.