Effect of Exogenous Wild Type p53 on Melanoma Cell Death Pathways Induced by Irradiation at Different LET

• 作者: Min Fengling Zhang Hong Li Wenjian Liu Bing Duan Xin Zhou Qingming
• 来源期刊: 近代物理研究所和兰州重离子加速器实验室年报：英文版
• 学科: 生物学
• 关键词: p53基因 辐射诱导 细胞死亡 黑色素瘤 野生型 通路 细胞凋亡 能量转移
• 年，卷（期）: 2005,（1）
• 页码范围: 91
• 页数: 1页
• 分类号: Q2

摘要

<正>We investigated the effect of exogenous wild type p53 on the radiation induced cells apoptosis and necrosis at different levels of linear energy transfer (LET) to evaluate its mechanisms. The human melanoma cell line A375,which bore wild-type p53 gene status was used, as well as the transfectant A375 cells (A375/p53) with adenoviral vector containing the wild-type p53 gene. We exposed these cells to X-rays and to accelerated carbon-ion(C-) beams. Carbon ions were accelerated by a heavy-ion accelerator at Insti-