Effects of cyhalothrin on the transient outward potassium current in central neurons of Helicoverpa armigera

• 来源期刊: 中国昆虫科学（英文版）
• 关键词: cyhalothrin Helicoverpa armigera patch clamp potassium channel
• 年，卷（期）: 2006,（1）
• 页码范围: 13-17
• 页数: 5页
• 语种: 英文

摘要

The effects of cyhalothrin on the transient outward potassium current in central neurons ofHelicoverpa armigera were studied by using the patch clamp techniques. The results showed that before using cyhalothrin (10-5 mmol/L), activation potential was approximately -40 mV, after application of the drug, the activation potential shifted roughly 10 mV to the negative potential direction, so channels can be activated more easily. Before and after cyhalothrin application, the change of current amplitude was insignificant. The value of V1/2 and k of activation curves did not change significantly,however, the V1/2 of the inactivation curves changed significantly. Inactivation curves significantly shifted to a negative direction, so that inactivation of the channels was hastened. It is indicated that there may exit a primary way in which cyhalothrin provides neurotoxicity to the nervous system through the regulation of activation potentials and inactivation state of IA channels.