EXPRESSION AND REGULATION OF IL-22 IN THE IL-17-PRODUCING CD4+T LYMPHOCYTES

• 来源期刊: 细胞研究(英文版)
• 学科: 生物学
• 关键词: 日月
• 年，卷（期）: 2006,（11）
• 页码范围: 902-907
• 页数: 6页
• 分类号: Q2
• 语种: 英文
• DOI: 10.1038/SJ.CR.7310106

摘要

IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against infection.Although CD4+helper T lymphocytes(TH)were found as a source of IL-22,the regulation of this cytokine has beenpoorly understood.Here,we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of THcells that also makes IL-17.IL-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA analysis.H...