The interaction of intense femtosecond laser pulses with hydrogen clusters has been experimentally studied.The hydrogen clusters were produced from expansion of high-pressure hydrogen gas (backed up to 8x106pa) into vacuum through a conical nozzle cryogenically cooled by liquid nitrogen.The average size of hydrogen clusters was estimated by Rayleigh scattering measurement and the maximum proton energy of up to 4.2keV has been obtained from the Coulomb explosion of hydrogen clusters under 2×1016W/cm2 laser irradiation.Dependence of the maximum proton energy on cluster size and laser intensity Was investigated,indicating the correlation between the laser intensity and the cluster size.The maximum proton energy is found to be directly proportional to the laser intensity,which is consistent with the theoretical prediction.