A multiscale model for analyzing the synergy of CS and WSS on the endothelium in straight arteries

• 来源期刊: 力学学报（英文版）
• 年，卷（期）: 2006,（1）
• 页码范围: 76-83
• 页数: 8页
• 语种: 英文

摘要

A multiscale model was proposed to calculate the circumferential stress (CS) and wall shear stress (WSS) and analyze the effects of global and local factors on the CS,WSS and their synergy on the arterial endothelium in large straight arteries.A parameter pair [Zs,SPA] (defined as the ratio of CS amplitude to WSS amplitude and the phase angle between CS and WSS for different harmonic components,respectively) was proposed to characterize the synergy of CS and WSS.The results demonstrated that the CS Or WSS in the large straight arteries iS determined bv the global factors,i.e.the preloads and the aflerloads,and the local factors,i.e.the local mechanical properties and the zero-stress states of arterial walls,whereas the Zs and S P A are primarily determined by the local factors and the arerloads.Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds,the stress amplitude ratio ZS and the stress phase difierence S P A might be appropriate indices to reflect the influences Of the states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis,vascular remodeling and atherosgenesis.