Glucose-lowering Activity of Amino Acid-N-phosphonic Acid Oxovanadium Complexes and Its Interaction with DNA

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2006,（12）
• 页码范围: 1721-1724
• 页数: 4页
• 语种: 英文

摘要

Vanadium has well-documented lowering glucose properties both in vitro and in vivo. The design of new oxovanadium(Ⅳ) coordination compounds, intended for use as insulin-enhancing agents in the treatment of diabetes mellitus, can potentially benefit from a synergistic approach, in which the whole complex has more than an additive effect from its component parts. Biological testing with oxovanadium(Ⅳ) organic phosphonic acid, for insulin-enhancing potential included acute administration, by oral gavage in streptozotocin (STZ) diabetic rats. The complexes of oxovanadium(Ⅳ) amino acid-N-phosphonic acid exhibit higher lowering glucose activity in vivo. The interaction of the complexes of oxovanadium(Ⅳ) amino acid-N-phosphonic acid with DNA was investigated by agarose gel electrophoresis. The results indicated that these complexes have strong interaction with DNA.