PanK4 inhibits pancreatic β-cell apoptosis by decreasing the transcriptional level of pro-caspase-9

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2007,（11）
• 页码范围: 966-968
• 页数: 3页
• 语种: 英文

摘要

Dear Editor: Coenzyme A(CoA)is a primary and predominant acyl group carrier involved in a wide variety of important biochemical processes.The CoA biosynthetic pathway is composed of five enzymatic steps,of which Pantothenate kinase(PanK)is a key regulatory enzyme.The multiple isoforms of PanK are encoded by four difierent genes[1,2].In our previous studies of SNP markers by genotyping the case-controlled DNAs,we found that one SNP within the hPANK4 gene on chromosome 1 was associated with type 2diabetes[3-5].We subsequently showed that rat PanK4 (rPanK4)was up-regulated when rats were challenged by high concentration ofglucose[6].M2-type pyruvate kinase (Pkm2)was found,both in vitro and in vivo,to be associated with rPanK4[7].