A Simple One-pot Synthesis of 3,5-Dicyano-1,2-dihydropyrid-2-ones in Aqueous Media

• 来源期刊: 中国化学(英文版)
• 年，卷（期）: 2007,（10）
• 页码范围: 1568-1572
• 页数: 5页
• 语种: 英文

摘要

A simple and clean synthesis of 3,5-dicyano-1,2-dihydropyrid-2-ones by a one-pot three-component reaction of malononitrile, aromatic aldehydes and 2-cyanoacetamide or 2-cyanothioacetamide has been achieved in an aqueous solution with potassium carbonate as a base under microwave irradiation without a phase transfer reagent. This protocol has the advantages of short reaction time (5-8 min) and convenient work-up.